.standardPanel_content .Bullet.custom-list sup {
  line-height: 1.25em;
}

.anchor_anchor {
  scroll-margin-top: var(--scroll-margin);
  display: block;
}

.siteMain > .title-container {
  padding-top: 0;
  padding-bottom: 0;
}

.heading-title-mbc {
  margin-top: 20px;
  margin-bottom: 0;
}

.red-bottom-border {
  border-bottom: .1em solid var(--color-red-30);
}

.trial-results-discontinuation-rates-wrapper .rates-column .rates-column-content.placebo,
.trial-results-discontinuation-rates-wrapper .rates-column .rates-column-heading.placebo {
  color: var(--color-black-90);
}

.font-size-13 {
  font-size: 13px;
}

.adverse-reactions {
  background-color: var(--color-gray-40);
  padding: 2.5em clamp(1.25vw, 5vw, 6vw) 1.5em;
  margin-top: 1.75em;
  margin-bottom: 1.75em;
}

.adverse-reactions h2 {
  margin-bottom: 1px;
}

.adverse-reactions > span {
  color: var(--color-black);
  font-weight: bold;
}

.boxedRTEPanelOne_box {
  --background-color: unset;
  --padding: 0;
  --line-width: 0;
  background-color: var(--background-color);
}

.boxedRTEPanelOne_box_no_bg {
  --background-color: unset;
  --padding: 0;
  --line-width: 0;
}

.boxedRTEPanelOne_buttons__container {
  padding-top: 1em;
  display: flex;
  flex-direction: column;
  gap: 1em;
}

.boxedRTEPanelOne_container {
  padding: var(--padding);
}

.boxedRTEPanelOne_content {
  max-width: 60em;
  width: 100%;
}

.boxedRTEPanelOne_content ul {
  margin-left: 1.25em;
}

.ctaCallout_ctaCallout {
  align-items: center;
  border-style: solid;
  border-width: 0.625em 0 0;
  border-color: var(--border-color);
  display: flex;
  flex-direction: column;
  justify-content: flex-start;
  padding: 2.5em 1.5625em 0;
  border: none;
}

.ctaCallout_ctaCalloutContent {
  display: flex;
  flex-direction: column;
  align-items: center;
  margin-bottom: 1.875em;
}

.ctaCallout_ctaIcon {
  margin-bottom: 0.9375em;
  max-width: 4.0625em;
  height: 4.1875em;
}

.ctaCallout_ctaCallout__text {
  text-align: center;
}

.ctaCallout_ctaCallout__description p {
  font-weight: var(--font-weight-medium);
  margin-bottom: 0;
  font-size: 1.125em;
}

.discontinuation-rates-wrapper,
.trial-results-discontinuation-rates-wrapper {
  align-items: center;
  display: flex;
}

.discontinuation-rates-wrapper p,
.trial-results-discontinuation-rates-wrapper p {
  margin: 0;
}

.discontinuation-rates-wrapper {
  margin-top: 1.875em;
}

.trial-results-discontinuation-rates-wrapper {
  justify-content: space-between;
  margin: 0 auto;
  max-width: 70%;
}

.discontinuation-rates-wrapper .rates-column,
.trial-results-discontinuation-rates-wrapper .rates-column {
  align-items: center;
  display: flex;
  flex-direction: column;
}

.discontinuation-rates-wrapper .rates-column .rates-column-content,
.discontinuation-rates-wrapper .rates-column .rates-column-heading,
.trial-results-discontinuation-rates-wrapper .rates-column .rates-column-content,
.trial-results-discontinuation-rates-wrapper .rates-column .rates-column-heading {
  font-weight: var(--font-weight-bold);
  text-transform: uppercase;
}

.trial-results-discontinuation-rates-wrapper .rates-column .rates-column-heading {
  font-size: 1.575em;
}

.trial-results-discontinuation-rates-wrapper .rates-column .rates-column-content {
  font-size: 4.875em;
  color: var(--color-black-90);
}

.discontinuation-rates-wrapper .rates-column .rates-column-heading {
  font-size: 2.575em;
}

.discontinuation-rates-wrapper .rates-column .rates-column-content {
  font-size: 5.875em;
}

.discontinuation-rates-wrapper .rates-column:first-of-type .rates-column-content,
.discontinuation-rates-wrapper .rates-column:first-of-type .rates-column-heading,
.trial-results-discontinuation-rates-wrapper .rates-column:first-of-type .rates-column-content,
.trial-results-discontinuation-rates-wrapper .rates-column:first-of-type .rates-column-heading {
  color: var(--color-blue-60);
}

.trial-results-discontinuation-rates-wrapper .rates-column-separator {
  display: flex;
  font-size: 1.875em;
  justify-content: center;
  margin: 0 1em;
  text-transform: uppercase;
}

.rates-column-separator-2 {
  color: var(--color-black-90);
  font-size: 2.57em;
  justify-content: center;
  margin: 0 1em;
  text-transform: uppercase;
}

.permanent-discontinuation-header {
  font-size: 1.875em;
  color: var(--color-blue-60);
  text-align: center;
}

.discontinuation-rates-wrapper-fit-content {
  width: fit-content;
  margin: auto;
}

.rates-column-content-gradient {
  background: linear-gradient(to right, var(--color-blue-60), var(--color-teal-70), var(--color-blue-70), var(--color-blue-80));
  -webkit-text-fill-color: transparent;
  -webkit-background-clip: text;
  background-clip: text;
}

.rates-column-separator-black {
  color: var(--color-black-90);
  font-size: 2.57em;
  justify-content: center;
  margin: 0 1em;
  text-transform: uppercase;
}

.rates-column-black {
  color: var(--color-black-90);
}

.discontinuation-rates-wrapper p.rates-column-separator-2 {
  color: var(--color-black-90);
  font-size: 2.57em;
  justify-content: center;
  margin: 0 1em;
  text-transform: uppercase;
}

.discontinuation-rates-list {
  margin-left: 10px;
}

.graphImage_image {
  width: 100%;
  margin-top: 1em;
}

.standardPanel_content hr {
  border-top: .1875em solid var(--color-red-30);
  width: 100%;
  display: inline-block;
  margin: 10px 0 0;
}

.safety-profile-header {
  display: inline;
  margin-bottom: 10px;
}

.safety-profile-header span {
  vertical-align: top;
  font-size: 15px;
  display: inline;
  padding-left: 0;
}

.safety-profile-date {
  color: var(--color-black);
}

.adverse {
  margin-bottom: 0;
  color: var(--color-gray-90);
}

.textCallout_textCallout {
  padding: 2em 1.25em 1.5em;
  background-color: var(--backgroundColor);
  border-top-right-radius: 1.3125em;
  border-bottom-left-radius: 1.3125em;
}

.textCallout_textCalloutContent {
  width: 100%;
}

.textCallout_descriptionText {
  width: 100%;
}

.textCallout_descriptionText * {
  margin-bottom: 0;
}

.textCallout_descriptionText .permanent-discontinuation-header {
  margin-bottom: 10px;
}

.textCallout_contentDisplay {
  display: flex;
  align-items: center;
}

.textCallout_bg_light_blue {
  --backgroundColor: var(--color-light-blue);
}

.textCallout_bg_light_green {
  --backgroundColor: var(--color-light-green-10);
}

.patients-text {
  text-align: start;
  color: var(--color-blue-60);
}

.patients-text-inner {
  font-size: 18px;
}

.trialDataTable_table {
  width: 100%;
  overflow-x: auto;
}

.trialDataTable_table strong span {
  font-size: 24px;
}

.trialResultsPanel_panelTitle {
  font-size: 1.5em;
  font-weight: var(--font-weight-bold);
  margin-bottom: 0.5em;
}

.trialResultsPanel_subtitle {
  font-size: 1.125em;
  font-weight: var(--font-weight-medium);
  margin-bottom: 0.5em;
}

.trialResultsPanel_middleSection {
  display: flex;
  flex-direction: row;
  gap: 2.25em;
  margin: 1.5em 0;
}

.trialResultsPanel_graphImageLeft {
  width: 100%;
}

.trialResultsThirdColumn_placeholderContainer {
  width: 100%;
  background-color: var(--backGround);
  margin: 1em 0;
}

.permanent-discontinuation-rates {
  font-size: 1.5em;
  color: var(--color-blue-60);
  font-family: var(--font-family-headings);
}

.teaes-leading-to-death {
  background-color: var(--color-white);
}

@media (min-width: 48em) {
  .boxedRTEPanelOne_content :where(h1, h2, h3, h4, h5, h6) {
    font-size: 1.375rem;
  }

  .boxedRTEPanelOne_buttons__container {
    flex-direction: row;
    gap: 1.5em;
  }

  .ctaCallout_ctaCallout {
    border-width: 0 0 0 0.625em;
    justify-content: flex-start;
    flex-direction: inherit;
    padding: 1.25em 0;
  }

  .ctaCallout_ctaCalloutContent {
    margin-left: 0;
    margin-bottom: 0;
    margin-right: auto;
    align-items: center;
    flex-direction: inherit;
  }

  .ctaCallout_ctaIcon {
    margin: -0.625em 1.875em 0 0;
  }

  .ctaCallout_ctaCallout__text {
    text-align: unset;
    display: flex;
    flex-wrap: wrap;
    align-items: center;
  }

  .ctaCallout_ctaCallout__description p,
  .ctaCallout_ctaCallout__link {
    margin-bottom: 0;
    margin-right: 0.3125em;
    display: flex;
    align-items: center;
  }

  .textCallout_textCallout {
    width: fit-content;
    padding: 20px;
  }

  .textCallout_textCalloutContent {
    display: flex;
    align-items: center;
    gap: 2.375em;
  }

  .trialResultsPanel_panelTitle {
    font-size: 2em;
  }

  .trialResultsPanel_subtitle {
    font-size: 1.375em;
  }
}

@media (min-width: 62.0625em) {
  .ctaCallout_ctaCallout__description p,
  .ctaCallout_ctaCallout__link {
    font-size: 1.375em;
  }

  .ctaCallout_ctaCallout__description p {
    line-height: 1.22;
  }

  .graphImage_imageWrapper {
    max-width: 33.33%;
    width: 100%;
  }

  .graphImage_image {
    width: 100%;
    margin-top: unset;
  }

  .trialResultsThirdColumn_placeholderContainer {
    max-width: 33.33%;
    margin: 0;
    width: 100%;
  }
}