.red-bottom-border {
  border-bottom: 0.1em solid var(--color-red-30);
}

.sm-text-left-align-all {
  position: relative;
  left: -6px;
  display: flex;
}

.dosing .dose-box.box-6 {
  background-color: initial;
}

.scroll-margin-anchor.anchor-point {
  scroll-margin-top: var(--scroll-margin);
  display: block;
}

.button-container {
  padding-top: 1em;
  display: flex;
  flex-direction: column;
  gap: 1em;
}

.action-button {
  font-weight: var(--font-weight-semibold);
  width: 100%;
}

.icon-button {
  display: flex;
  flex-direction: row-reverse;
  align-items: center;
  gap: 0.5em;
}

.icon-button .icon {
  fill: var(--color-white);
  height: 0.875em;
  max-width: 0.875em;
  min-width: 0.875em;
  width: 100%;
}

.icon-button:hover .icon {
  fill: var(--color-white);
}

.panel-container {
  padding: var(--padding);
}

.panel-content {
  max-width: 60em;
  width: 100%;
}

.panel-content:where(h1, h2, h3, h4, h5, h6) {
  margin-bottom: 0.5em;
  font-weight: var(--font-weight-medium);
  color: var(--color-blue-60);
  font-size: 1.125em;
}

.panel-content hr {
  overflow: visible;
  border-top: 1px solid var(--color-teal-50);
  position: relative;
  width: calc(100% + var(--line-width));
  margin: 1.5em 0;
}

.panel-content hr::before {
  position: absolute;
  background-color: var(--color-teal-50);
  content: "";
  height: 0.625em;
  width: 0.625em;
  bottom: 0.3125em;
  left: -0.0625em;
  top: -0.3125em;
}

.panel-content ul li::marker {
  color: var(--color-teal-50);
}

.cta-callout {
  align-items: center;
  border-style: solid;
  border-width: 0.625em 0px 0px;
  border-color: var(--border-color);
  display: flex;
  flex-direction: column;
  justify-content: flex-start;
  padding: 2.5em 1.5625em 0px;
}

.cta-content {
  display: flex;
  flex-direction: column;
  align-items: center;
  margin-bottom: 1.875em;
}

.cta-icon {
  margin-bottom: 0.9375em;
  max-width: 4.0625em;
  height: 4.1875em;
}

.cta-text {
  text-align: center;
}

.cta-description p {
  font-weight: var(--font-weight-medium);
  margin-bottom: 0px;
  font-size: 1.125em;
}

.cta-callout {
  border: none;
}

.small-text {
  font-size: 13px;
}

.dosing .full-width-content {
  padding-top: 1.75em;
  max-width: 100%;
}

.heading-small-margin {
  margin-bottom: 10px;
}

.no-left-margin {
  margin-left: 0;
}

.dosage-heading {
  font-size: 32px;
}

.blue-text {
  color: var(--color-blue-60);
  font-family: var(--font-family-headings);
}

.blue-text-lowercase {
  color: var(--color-blue-60);
  text-transform: lowercase;
  font-family: var(--font-family-headings);
}

.trastuzumab-heading {
  position: relative;
  top: 8px;
}

.sup-styling {
  font-size: 22px;
  position: relative;
  top: 4px;
  left: -1px;
  font-weight: 500;
}

.desktop-image {
  display: none;
}

.mobile-image {
  width: 100%;
}

.image-padding {
  padding-left: 1em;
  padding-right: 1em;
}

.dose-wrapper {
  display: flex;
  flex-wrap: wrap;
  width: 100%;
  margin-top: 2em;
  row-gap: 1.5em;
}

.dose-headline {
  font-weight: var(--font-weight-medium);
  font-size: 1.125em;
}

.dose-desc-wrap {
  margin-bottom: 1em;
}

.dose-panel {
  width: 100%;
  text-align: center;
  position: relative;
  row-gap: 1.5em;
  margin-bottom: 1.5em;
}

.dose-panel::after {
  position: absolute;
  content: "";
  bottom: -2.1875em;
  border-top: 0.625em solid var(--color-black-light);
  border-bottom: 0.625em solid var(--color-black-light);
  border-left: 0.625em solid var(--color-teal-70);
  transform: rotate(90deg);
}

.dose-panel:last-child::after {
  display: none;
}

.dose-box {
  position: relative;
  background-color: var(--color-teal-10);
  border: 0.0625em solid var(--color-teal-70);
  color: var(--color-teal-50);
  padding: 1em 1.5em;
}

.dose-container {
  width: 100%;
  position: relative;
}

.dose-title {
  color: var(--color-black-70);
  font-size: 1.125em;
  font-weight: var(--font-weight-bold);
  margin-bottom: 0.75em;
}

.dose-mg {
  font-weight: var(--font-weight-bold);
  font-size: 1.625em;
  margin-bottom: 0.5em;
}

.dose-freq {
  font-weight: var(--font-weight-bold);
  text-transform: uppercase;
  margin-bottom: 0;
}

.content-panel :where(h1) {
  margin-bottom: 0;
}

.content-panel hr {
  border-top: 0.1875em solid var(--color-red-30);
  width: 100%;
  display: inline-block;
  margin: 1.25em 0;
}

.content-panel strong span {
  display: contents;
}

.text-callout {
  padding: 2em 1.25em 1.5em;
  background-color: var(--color-blue-15);
  border-top-right-radius: 1.3125em;
  border-bottom-left-radius: 1.3125em;
}

.callout-content {
  width: 100%;
}

.description-text {
  width: 100%;
}

.description-text * {
  margin-bottom: 0px;
}

.content-display {
  display: flex;
  align-items: center;
}

@media (min-width: 48em) {
  .panel-content :where(h1, h2, h3, h4, h5, h6) {
    font-size: 1.375rem;
  }

  .panel-content.no-pad {
    padding: 1.25em 2.75em 0 2.75em;
  }

  .boxed-panel-one.container.no-pad {
    padding: 0;
  }

  .button-container {
    flex-direction: row;
    gap: 1.5em;
    flex-wrap: wrap;
  }

  .btn-2 {
    padding-left: 2.75em;
    padding-bottom: 1.25em;
  }

  .action-button {
    width: fit-content;
  }

  .cta-callout {
    border-width: 0px 0px 0px 0.625em;
    justify-content: flex-start;
    flex-direction: inherit;
    padding: 1.25em 0px;
  }

  .cta-content {
    margin-left: 0px;
    margin-bottom: 0px;
    margin-right: auto;
    align-items: center;
    flex-direction: inherit;
  }

  .cta-icon {
    margin: -0.625em 1.875em 0px 0px;
  }

  .cta-text {
    text-align: unset;
  }

  .cta-description p,
  .cta-link {
    margin-bottom: 0px;
    margin-right: 0.3125em;
    display: flex;
    align-items: center;
  }

  .cta-text {
    display: flex;
    flex-wrap: wrap;
  }

  .desktop-image {
    display: block;
    width: 100%;
  }

  .mobile-image {
    display: none;
  }
  .image-padding {
    padding-right: 2.75em;
    padding-left: 2.75em;
  }

  .dose-wrapper {
    margin-bottom: 1.5em;
  }

  .dose-headline {
    font-size: 1.375em;
  }

  .dose-panel {
    position: relative;
    margin-right: 2.625em;
    max-width: 16.5625em;
    margin-bottom: 0;
  }

  .dose-panel::after {
    right: -1.5625em;
    bottom: 25%;
    transform: rotate(0deg);
  }

  .dose-container {
    max-width: 16.5625em;
    position: relative;
    margin-right: 2.625em;
  }

  .dose-box::after {
    transform: rotate(0deg);
    bottom: 36%;
    right: -1.75em;
  }

  .text-callout {
    width: fit-content;
    padding: 20px;
  }
  .callout-content {
    display: flex;
    align-items: center;
    gap: 2.375em;
  }
}

@media (min-width: 62.0625em) {
  .cta-description p,
  .cta-link {
    font-size: 1.375em;
  }

  .panel-content.no-pad {
    padding: 0;
  }

  .boxed-panel-one.container.no-pad {
    padding: 1.25em 6.365em;
  }

  .btn-2 {
    padding-left: 0;
    padding-bottom: 0;
  }

  .cta-description p {
    line-height: 1.22;
  }

  .image-padding {
    padding-right: 6.375em;
    padding-left: 6.375em;
  }
}